CQBS Research: Software Development
MCell (Monte Carlo cell) is a program that uses spatially realistic 3-D cellular models, a specialized Model Development Language (MDL), and specialized Monte Carlo algorithms to simulate the movements and reactions of molecules within and between cells—cellular microphysiology. MCell development is a collaborative project between the CQBS and colleagues in the Computational Neurobiology Laboratory at the Salk Institute. Current work centers on newly expanded algorithms for interactions between arbitrary numbers of diffusing chemical species in solution and/or in membranes (MCell v3.x), and hybrid methods for coupled, multi-scale Monte Carlo-finite element-finite volume simulations. Development of a new parallel MCell version is also a future goal, and plans are underway with collaborators in the Computer Science Department at the University of California San Diego.
MCell 3.3 and DReAMM 3.3.0 Now Available
New versions for Linux and Mac OS X now available on our Downloads page.
MCell Used in New Vesicle Fusion Findings
Researchers at the National Institute of Neurological Disorders and Stroke use MCell to simulate "kiss-and-run" fusion at calyx-type synapses. See He, L., et al. Two modes of fusion pore opening revealed by cell-attached recordings at a synapse. Nature 444, 102-105 (2006).
MCell and DReAMM Demographics and Teaching Statistics
Check out CQBS's most recent usage statistics. [Read more]