Center for Quantiative Biological Simulation Microphysiology Gateway

CQBS Research: Selected Publications

• Luo, F, Stiles, JR, and Meriney, SD (in preparation) Variance analysis of action potential-evoked calcium influx reveals low opening probability of presynaptic calcium channels at the frog neuromuscular junction.



• Pattillo, JM, Meriney, SD, and Stiles, JR. (submitted) Design principles of neurotransmitter exocytosis predicted by spatially realistic Monte Carlo simulations.



• Coggan, JS, Bartol, TM, Esquenazi, E, Stiles, JR, Lamont, S, Martone, ME, Berg, DK, Ellisman, MH, and Sejnowski, TJ. (2005) Evidence for ectopic neurotransmission at a neuronal synapse.  Science 309:446-451.



• Stiles, JR, Ford, WC, Pattillo, JM, Deerinck, TE, Ellisman, MH, Bartol, TM, and Sejnowski, TJ. (2004) Spatially realistic computational physiology: past, present, and future. In: Parallel Computing: Software Technology, Algorithms, Architectures & Applications, ed. Joubert, G, et al. Elsevier, Amsterdam, pp. 685-694.



• Wachman, ES, Poage, RE, Stiles, JR, Farkas, DL, and Meriney, SD. (2004) Spatial distribution of calcium entry evoked by single action potentials within the presynaptic active zone. J. Neurosci. 24:2877-2885.



• Gomez, CM, Maselli, RA, Vohra, BP, Navedo, M, Stiles, JR, Charnet, P, Schott, K, Rojas, L, Keesey, J, Verity, A, Wollmann, RW, and Lasalde-Dominicci, J. (2002) Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms. Ann. Neurol. 51:102-112.



• Stiles, JR, and Bartol, TM. (2001) Monte Carlo methods for simulating realistic synaptic microphysiology using MCell. In: Computational Neuroscience: Realistic Modeling for Experimentalists, ed. De Schutter, E. CRC Press, Boca Raton, pp. 87-127.  CD-ROM material available at http://www.compneuro.org/CDROM.



• Stiles, JR, Bartol, TM, Salpeter, MM, Salpeter, EE, and Sejnowski, TJ. (2001) Synaptic variability: new insights from reconstructions and Monte Carlo simulations with MCell. In: Synapses, ed. Cowan, WM, Stevens, CF, and Sudhof, TC. Johns Hopkins Univ. Press, Baltimore, pp. 681-731.



• Stiles, JR, Kovyazina, IV, Salpeter, EE, and Salpeter, MM. (1999). The temperature sensitivity of miniature endplate currents is mostly governed by channel gating: evidence from optimized recordings and Monte Carlo simulations. Biophys. J. 77:1177-1187.



• Stiles, JR, Bartol, TM, Jr, Salpeter, EE, and Salpeter, MM. 1998. Monte Carlo simulation of neurotransmitter release using MCell, a general simulator of cellular physiological processes. In: Computational Neuroscience, ed. Bower, JM. Plenum, NY. pp. 279-284.



• Stiles, JR, Van Helden, D, Bartol, TM, Jr., Salpeter, EE, and Salpeter, MM. 1996. Miniature endplate current rise times <100 μ from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle. Proc. Natl. Acad. Sci. USA 93:5747-5752.